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CACNA1H Antibody

CAT: 0223-8029-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8029-01Size:0.02 mg
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Background
The calcium channel protein CACNA1H is a T-type member of the alpha-1 subunit family that is part of the voltage-dependent calcium channel complex which mediates the influx of calcium ions into the cell upon membrane polarization (1,2) . CACNA1H is a subunit of Cav3.2 T-type calcium channel that is involved in neurological disorders such as epilepsy and pain (2,3) . CACNA1H associates with the caveolin protein Cav-3 and it is thought that Cav-3 regulates the Protein Kinase A (PKA) modulation of CACNA1H-containing Cav3.2 T-type calcium channels (4) .
NCBI Gene ID
8912
Swiss Prot
O95180
Accession Number
NP_066921
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
CACNA1H antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
CACNA1H antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CACNA1H antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
CACNA1H antibody is human, mouse and rat reactive. Multiple isoforms of CACNA1H are known to exist.
Symbol
CACNA1H
NCBI Official Name
Calcium channel, voltage-dependent, T type, alpha 1H subunit
NCBI Organism
Homo sapiens
Background Reference 01
Cribbs LL, Lee JH, Yang J, et al. Cloning and characterization of alpha1H from human heart, a member of the T-type CA2+ channel gene family. Circ. Res. 1998; 83:103-9.
Background Reference 02
Sekiguchi F and Kawabata A. T-type calcium channels: functional regulation and implication in pain signaling. J. Pharmacol. Sci. 2013; 122:244-50.
Background Reference 03
McGivern JG. Targeting N-type and T-type calcium channels for the treatment of pain. Drug Discov. Today 2006; 11:245-53.
Background Reference 04
Markandeya YS, Fahey JM, Pluteanu F, et al. Caveolin-3 regulates protein kinase A modulation of the Cav3.2 (a1H) T-type Ca2+ channels. J. Biol. Chem. 2011; 286:2433-2444.
Other Product Names
Calcium channel voltage-dependent T type alpha 1H subunit, CACNA1HB, Cav3.2, ECA6, EIG6
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
53832009
Physical Properties
Liquid

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