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SAMHD1 Antibody

CAT: 0223-8007-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-8007-01Size:0.02 mg
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Background
The SAM domain and HD domain 1 (SAMHD1) protein is upregulated in response to viral infection and is thought to play a role in innate immunity (1) . SAMHD1 blocks the infection of HIV-1 and SIVdeltaVpx before reverse transcription in macrophages and dendritic cells (2), and this restriction is regulated by phosphorylation of SAMHD1 (3) . Mutations in this gene have been associated with Aicardi-Goutieres syndrome (1) .
NCBI Gene ID
25939
Swiss Prot
Q9Y3Z3
Accession Number
NP_056289
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
8007
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
KO Validation (Figure 5) shows SAMHD1 expression detected by anti-SAMHD1 antibodies (8007) was disrupted in multiple cells of SAMHD1 KO mice (figure 6) . KO Validation (8007) Overexpression validation (Figure 2,6,7) : SAMHD1 overexpression detected by anit-SAMHD1 antibodies (8007) was observed in normal cell lines stably across all healthy donors. Overexpression validation8007 Regulated expression validation (Figure 8 & 9) : SAMHD1 expression detected by anit-SAMHD1 antibodies (8007) was down-regulated by nucleofection with miR-181b at 48hr (figure 8), but up-regulated by treatment of miR-181family inhibitor (figure 9) . Regulated expression validation8007
Field of Research
Innate Immunity
Purification
SAMHD1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1224 - Daudi Cell Lysate
Concentration
1 mg/mL
Buffer
SAMHD1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SAMHD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SAMHD1 antibody is human and mouse reactive.
Isoform
Human SAMHD1 has 3 isoforms, including isoform 1 (626aa, 72kD), isoform 3 (556aa, 64kD), isoform 4 (591aa, 68kD) . Mouse SAMHD1 has 2 isoforms, including (658aa, 76kD) and (651aa, 75kD) . Rat SAMHD1 has only one isoform (620aa, 72kD) . 8007 can detect human, mouse and rat.
Symbol
SAMHD1
NCBI Official Name
SAM domain and HD domain 1
NCBI Organism
Homo sapiens
Background Reference 01
Rice et al. Nat. Genet. 2009; 41:829-32.
Background Reference 02
Hrecka et al. Nature 2011; 474:654-7.
Background Reference 03
Welbourn et al. J. Virol. 2013; 87:11516-24.
Citation 01
29911928
Citation 02
27889686
Citation 03
29321329
Citation 04
26580513
Other Product Names
SAM domain and HD domain 1, DCIP, CHBL2, HDDC1, MOP-5, SBBI88
Tested Applications
ELISA, WB, IHC, IF
Protein ID
38016914
Physical Properties
Liquid

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