Products for Research Use Only
RegisterLogin

SMURF1 Antibody

CAT: 0223-7945-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-7945-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1) . SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2) . SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3) . SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4) .
NCBI Gene ID
57154
Swiss Prot
Q9HCE7
Accession Number
NP_065162
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Cancer
Purification
SMURF1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
SMURF1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SMURF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SMURF1 antibody is human, mouse and rat reactive. At least three isoforms of SMURF1 are known to exist this antibody will recognize all three isoforms. SMURF1 is predicted to not cross-react with SMURF2.
Symbol
SMURF1
NCBI Official Name
SMAD specific E3 ubiquitin protein ligase 1
NCBI Organism
Homo sapiens
Background Reference 01
Huibregtse JM, Scheffner M, Beaudenon S, et al. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 1995; 92:2563-7.
Background Reference 02
Hwang YS, Lee HS, Kamata T, et al. The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. Genes Dev. 2013; 27:491-503.
Background Reference 03
Yamashita M, Ying SX, Zhang G, et al. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005; 121:101-113.
Background Reference 04
Kwon A, Lee HL, Woo KM, et al. SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion. Mol. Cells 2013; 36:548-55.
Other Product Names
SMAD specific E3 ubiquitin protein ligase 1, SMAD ubiquitination regulatory factor 1, E3 ubiquitin-protein ligase SMURF1
Tested Applications
ELISA, WB, IHC-P
Protein ID
31317292
Physical Properties
Liquid

Related Products

CatalogName
7945PSMURF1 Peptide
7773-01mgSMURF2 Antibody
7773-002mgSMURF2 Antibody
7773-01SMURF2 Antibody
59-190SMUG1 Antibody
13-478SMUG1 Antibody
46-390SMUG1 Antibody
7773PSMURF2 Peptide
23-794SMU1 Antibody
46-390PSMUG1 Peptide

Alternative Products

CatalogName
70R-20411SMURF1 antibody

Popular Products