Products for Research Use Only
RegisterLogin

NOX4 Antibody

CAT: 0223-7927-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-7927-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide (1) . NOX4 is is expressed in multiple tissues and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS) (2,3) . Unlike other NOX proteins, NOX4 does not require cytosolic subunits and thus is constitutively active (4) . The function of NOX4 remains unclear as it plays both protective and deleterious roles in cellular metabolism.
NCBI Gene ID
50507
Swiss Prot
Q9NPH5
Accession Number
NP_058627
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
NOX4 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
NOX4 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NOX4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
NOX4 antibody is human, mouse, and rat reactive. At least four isoforms of NOX4 are known to exist. NOX4 is predicted to not cross-react with other NOX proteins.
Symbol
NOX4
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
NADPH oxidase 4
NCBI Organism
Homo sapiens
Background Reference 01
Bedard K and Krause KH. The Nox family of ROS-generating NAPDH oxidases: physiology and pathophysiology. Physiol. Rev. 2007; 87:245-313.
Background Reference 02
Cheng G, Cao Z, Xu X, et al. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001; 269:131-40.
Background Reference 03
Montezano AC, Burger D, Ceravolo GS, et al. Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5. Clin. Sci. 2011; 120:131-41.
Background Reference 04
Martyn KD, Frederick LM, von Loehneysen K, et al. Functional analysis of Nox4 reveals unique characteristics compared to other NAPDH oxidases. Cell. Signal. 2006; 18:69-82.
Other Product Names
NAPDH oxidase 4, NOX-4, RENOX, KOX, KOX-1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
8393843
Physical Properties
Liquid

Related Products

CatalogName
7927PNOX4 Peptide
22-731NOX5 Antibody
7923-01mgNOX2 Antibody
2437-01mgNoxa Antibody
30-236NOX1 Antibody
42-144NOXA Antibody
7925-01mgNOX3 Antibody
7923-01NOX2 Antibody
7921-01mgNOX1 Antibody
42-316NOX1 Antibody

Alternative Products

CatalogName
GTR18119095-01NOX4 Antibody
GWB-ADBB12NOX4, Antibody

Popular Products