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PDCL2 Antibody

CAT: 0223-7887-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7887-01Size:0.02 mg
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Background
Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2) . PDCL2 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3) . PDCL2 has been shown to interact with the chaperonin CCT and is essential for cytoskeletal protein function and cell cycle progression (4) .
NCBI Gene ID
132954
Swiss Prot
Q8N4E4
Accession Number
NP_689614
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
PDCL2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
PDCL2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PDCL2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PDCL2 antibody is human, mouse and rat reactive. PDCL2 antibody is predicted to not cross-react with other members of the PDCL protein family.
Symbol
PDCL2
NCBI Official Name
Phosducin-like 2
NCBI Organism
Homo sapiens
Background Reference 01
Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.
Background Reference 02
Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.
Background Reference 03
Lou X, Bao R, Zhou CZ, et al. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallographica 2009; F65:67-70.
Background Reference 04
Stirling PC, Srayko M, Takhar KS, et al. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeltal protein function and cell cycle progrssion. Mol. Biol. Cell 2007; 18:2336-45.
Other Product Names
PDCL2 Antibody: GCPHLP, Phosducin-like protein 2
Tested Applications
ELISA, WB
Protein ID
51944950
Physical Properties
Liquid

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