PDCL2 Antibody

• Background :

  Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling (1,2) . PDCL2 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain (3) . PDCL2 has been shown to interact with the chaperonin CCT and is essential for cytoskeletal protein function and cell cycle progression (4) .

• NCBI Gene ID :

  132954

• Swiss Prot :

  Q8N4E4

• Accession Number :

  NP_689614

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  PDCL2 antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1464 - Rat Liver Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  PDCL2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  PDCL2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  PDCL2 antibody is human, mouse and rat reactive. PDCL2 antibody is predicted to not cross-react with other members of the PDCL protein family.

• Symbol :

  PDCL2

• NCBI Official Name :

  Phosducin-like 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Miles MF, Barhite S, Sganga M, et al. Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function. Proc. Natl. Acad. Sci. USA 1993; 90:10831-5.

• Background Reference 02 :

  Ruiz-Gomez A, Humrich J, Murga C, et al. Phosphorylation of phosducin and phosducinlike protein by G protein-coupled receptor kinase 2. J. Biol. Chem. 2000; 275:29724-30.

• Background Reference 03 :

  Lou X, Bao R, Zhou CZ, et al. Structure of the thioredoxin-fold domain of human phosducin-like protein 2. Acta Crystallographica 2009; F65:67-70.

• Background Reference 04 :

  Stirling PC, Srayko M, Takhar KS, et al. Functional interaction between phosducin-like protein 2 and cytosolic chaperonin is essential for cytoskeltal protein function and cell cycle progrssion. Mol. Biol. Cell 2007; 18:2336-45.

• Other Product Names :

  PDCL2 Antibody: GCPHLP, Phosducin-like protein 2

• Tested Applications :

  ELISA, WB

• Protein ID :

  51944950

• Physical Properties :

  Liquid