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TET1 Antibody

CAT: 0223-7733-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7733-01Size:0.02 mg
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Background
TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t (10;11) (q22; q23) (1) . It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2) . TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3) . Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4) .
NCBI Gene ID
80312
Swiss Prot
Q8NFU7
Accession Number
NP_085128
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
7733
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
TET1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 – Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%), Pig: (88%)
Buffer
TET1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TET1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.
Isoform
Human TET1 has one isoform (2136aa, 235kD) . Mouse TET1 has one isoform (2007aa, 219kD) and Rat TET1 also has one isoform (2033aa, 223kD) . 7733 can detect human, mouse and rat.
Symbol
TET1
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
Tet methylcytosine dioxygenase 1
NCBI Organism
Homo sapiens
Background Reference 01
Lorsbach, et al. Leukemia 2003; 17:637-41.
Background Reference 02
Tahilani , et al. Science 2009; 324:930-5.
Background Reference 03
Neves-Costa, et al. Immunol. 2013; 54:264-70.
Background Reference 04
Sun, et al. Sci. USA 2013; 110:9920-5.
Citation 01
26917720
Other Product Names
TET1 Antibody: LCX, CXXC6, bA119F7.1, KIAA1676, LCX, Methylcytosine dioxygenase TET1, CXXC-type zinc finger protein 6
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
156139122
Physical Properties
Liquid

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