CFTR Antibody

• Background:

  The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance (1,2) . CFTR functions as a chloride channel and controls the regulation of other transport pathways (3) . Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations (1) .

• NCBI Gene ID:

  1080

• Swiss Prot:

  P13569

• Accession Number:

  NP_000483

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  CFTR antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1308 - Human Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Sheep: (100%), Rabbit: (100%), Bovine: (95%), Pig: (89%), Horse: (89%), Guinea pig: (89%)

• Buffer:

  CFTR Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CFTR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  CFTR antibody is human, mouse and rat reactive.

• Symbol:

  CFTR

• Positive Control 2:

  Cat. No. 11-801 - Human Small Intestine Tissue Slide

• NCBI Official Name:

  Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989; 245:1073-80.

• Background Reference 02:

  Harris A and Argent BE. The cystic fibrosis gene and its product CFTR. Semin. Cell Biol. 1993; 4:37-44.

• Background Reference 03:

  Schwiebert EM, Benos DJ, Egan ME, et al. CFTR is a conductance regulator as well as a chloride channel. Physiol. Rev. 1999; 79:S145-66.

• Other Product Names:

  CFTR Antibody: CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, CFTR

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  90421313

• Physical Properties:

  Liquid