LAMTOR2 Antibody

• Background:

  The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2) . This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4) .

• NCBI Gene ID:

  28956

• Swiss Prot:

  Q9Y2Q5

• Accession Number:

  NP_054736

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  LAMTOR2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%)

• Buffer:

  LAMTOR2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  LAMTOR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.

• Symbol:

  LAMTOR2

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wunderlich W, Fialka I, Teis D, et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001; 152:765-76.

• Background Reference 02:

  Teis D, Wunderlich W, and Huber LA. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 2002; 3:803-14.

• Background Reference 03:

  Teis D, Taub N, Kurzbauer R, et al. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J. Cell Biol. 2006; 175:861-8.

• Background Reference 04:

  Taub N, Nairz M, Hilber D, et al. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J. Cell Sci. 2012; 125:2698-708.

• Other Product Names:

  LAMTOR2 Antibody: p14, ENDAP, ROBLD3, HSPC003, MAPBPIP, MAPKSP1AP, Ragulator2, Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, MAPBP-interacting protein

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  7661728

• Physical Properties:

  Liquid