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THAP11 Antibody

CAT: 0223-7613-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7613-01Size:0.02 mg
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Background
The THAP domain-contining protein 11 (THAP11), also known as Ronin, is an essential factor involved in embryonic stem (ES) cell pluripotency and cell growth (1) . THAP 11 contains a THAP domain, a conserved DNA-binding domain common to many proteins associated with chromatin modification and gene expression silencing, and has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases (2) . THAP11 can also negatively regulate CD44 v6 expression through its interaction with the poly (rC) binding protein PCBP1 (3) .
NCBI Gene ID
57215
Swiss Prot
Q96EK4
Accession Number
NP_065190
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
THAP11 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
THAP11 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
THAP11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
THAP11 antibody is human, mouse and rat reactive.
Symbol
THAP11
NCBI Official Name
THAP domain containing 11
NCBI Organism
Homo sapiens
Background Reference 01
Dejosez M, Krumenacker JS, Zitur LJ, et al. Ronin is essential for embryogenesis and the pluripotency of mouse ES cells. Cell 2008; 133:1162-74.
Background Reference 02
Roussigne M, Kossida S, Lavigne AC, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 2003; 28:66-9.
Background Reference 03
Lian WX, Yin RH, Kong XZ, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012; 586:1431-8.
Other Product Names
THAP11 Antibody: RONIN, CTG-B43a, CTG-B45d, HRIHFB2206, THAP domain-containing protein 11
Tested Applications
ELISA, WB
Protein ID
40354197
Physical Properties
Liquid

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