THAP11 Antibody

• Background :

  The THAP domain-contining protein 11 (THAP11), also known as Ronin, is an essential factor involved in embryonic stem (ES) cell pluripotency and cell growth (1) . THAP 11 contains a THAP domain, a conserved DNA-binding domain common to many proteins associated with chromatin modification and gene expression silencing, and has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases (2) . THAP11 can also negatively regulate CD44 v6 expression through its interaction with the poly (rC) binding protein PCBP1 (3) .

• NCBI Gene ID :

  57215

• Swiss Prot :

  Q96EK4

• Accession Number :

  NP_065190

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Stem Cell

• Purification :

  THAP11 antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine: (100%)

• Buffer :

  THAP11 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  THAP11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Specificity :

  THAP11 antibody is human, mouse and rat reactive.

• Symbol :

  THAP11

• NCBI Official Name :

  THAP domain containing 11

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dejosez M, Krumenacker JS, Zitur LJ, et al. Ronin is essential for embryogenesis and the pluripotency of mouse ES cells. Cell 2008; 133:1162-74.

• Background Reference 02 :

  Roussigne M, Kossida S, Lavigne AC, et al. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. Trends Biochem. Sci. 2003; 28:66-9.

• Background Reference 03 :

  Lian WX, Yin RH, Kong XZ, et al. THAP11, a novel binding protein of PCBP1, negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line. FEBS Lett. 2012; 586:1431-8.

• Other Product Names :

  THAP11 Antibody: RONIN, CTG-B43a, CTG-B45d, HRIHFB2206, THAP domain-containing protein 11

• Tested Applications :

  ELISA, WB

• Protein ID :

  40354197

• Physical Properties :

  Liquid