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TMEM107 Antibody

CAT: 0223-7483-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7483-01Size:0.02 mg
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Background
Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1) . It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2) . TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3) . TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3) .
NCBI Gene ID
84314
Swiss Prot
Q6UX40
Accession Number
NP_115730
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
TMEM107 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1208 - THP-1 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (86%), Rat: (86%)
Buffer
TMEM107 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TMEM107antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.
Symbol
TMEM107
Positive Control 2
Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide
NCBI Official Name
Transmembrane protein 107
NCBI Organism
Homo sapiens
Background Reference 01
Christopher KJ, Wang B, Kong Y, et al. Forward genetics uncovers transmembrane protein 107 as a novel factor required for ciliogenesis and sonic hedgehog signaling. Dev. Biol. 2012; 368:382-92.
Background Reference 02
Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003; 13:2265-70.
Background Reference 03
Ho KS and Scott MP. Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr. Opin. Neurobiol. 2002; 12:57-63.
Other Product Names
TMEM107 Antibody : GRVS638, PRO1268, Transmembrane protein 107
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
34101276
Physical Properties
Liquid

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