GABARAP Antibody

CAT: 0223-7359-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7359-01Size:0.02 mg
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Background
GABARAP Antibody: Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.
NCBI Gene ID
11337
Swiss Prot
O95166
Accession Number
NP_009209
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
GABARAP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Bovine: (100%)
Buffer
GABARAP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GABARAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
Multiple isoforms of GABARAP exist due to alternative splicing events.
Symbol
GABARAP
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
GABA (A) receptor-associated protein
NCBI Organism
Homo sapiens
Background Reference 01
Cherubini E, Gaiarsa JL, and Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci.1991; 14:515-19.
Background Reference 02
Dirkx R Jr, Thomas A, Li L, et al. Targeting of the 67 kDa isoform of glutamic acid decarboxylase to intracellular organelles is mediated by its interaction with the NH2-terminal region of the 65 kDa isoform of glutamic acid decarboxylase. J. Biol. Chem. 1995; 270:2241-6.
Background Reference 03
Wang H, Bedford FK, Brandon NJ, et al. GABA (A) -receptor-associated protein links GABAA receptors and the cytoskeleton. Nature 1999; 397:69-72.
Background Reference 04
Colecchia D, Strambi A, Sanzone S, et al. MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. Autophagy 2012 Sep 4;8 (12) .
Other Product Names
GABARAP Antibody: MM46, ATG8A, GABARAP-a, FLC3B, HT004, Gamma-aminobutyric acid receptor-associated protein, MM46
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
6005764
Physical Properties
Liquid

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