RNF20 Antibody

CAT: 0223-7357-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7357-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
RNF20 Antibody: RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS) . In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.
NCBI Gene ID
56254
Swiss Prot
Q5VTR2
Accession Number
NP_062538
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
RNF20 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (89%)
Buffer
RNF20 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RNF20 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
Multiple isoforms of RNF20 are known to exist.
Symbol
RNF20
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Ring finger protein 20, E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Zhu B, Zheng Y, Pham AD, et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 2005; 20:601-11.
Background Reference 02
Shema E, Kim J, Roeder RG, et al. RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol Cell 2011; 42:477-88.
Background Reference 03
Shema E, Tirosh I, Aylon Y, et al. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev. 2008; 22:2664-76.
Background Reference 04
Fuchs G, Shema E, Vesterman R, et al. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol. Cell 2012; 46:662-73.
Other Product Names
RNF20 Antibody: BRE1, BRE1A, hBRE1, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20, BRE1-A
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
34878777
Physical Properties
Liquid

Related Products

CatalogName
7357PRNF20 Peptide
14-349RNF10 Antibody
58-922RNF10 Antibody
60-080RNF24 Antibody
29-016RNF10 Antibody
8549-01mgRNF26 Antibody
8549-01RNF26 Antibody
29-844RNF40 Antibody
29-853RNF25 Antibody
62-029RNF208 Antibody

Alternative Products

CatalogName
MBS7044995-01RNF20 Antibody

Popular Products