FOXA1 Antibody

• Background:

  FOXA1 Antibody: FOXA1 is one of three members of the FOXA family, a subset of the forkhead family of transcription factors which play vital roles in development. It has also been implicated in the development of a number of other organs including the androgen and estrogen regulated tissues of the breast and prostate. FOXA1 modulates the transcriptional activity of nuclear hormone receptors and regulates apoptosis by inhibiting the expression of BCL-2. It is an essential protein for the transcriptional activity of both androgen receptor (AR) and estrogen receptor-α (ER) . FOXA1 plays a pivotal role from early stage cancer through to drug resistant and metastatic disease. FOXA1 is not only an attractive therapeutic target but could potentially function as a novel biomarker.

• NCBI Gene ID:

  3169

• Swiss Prot:

  P55317

• Accession Number:

  NP_004487

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  FOXA1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (86%), Rat: (79%)

• Buffer:

  FOXA1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  FOXA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  IgG

• Specificity:

  Multiple isoforms of FOXA1 exists as a result of alternative splicing event.

• Symbol:

  FOXA1

• NCBI Official Name:

  Forkhead box A1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hannenhalli S and Kaestner KH. The evolution of Fox genes and their role in development and disease. Nat. Rev. Genet. 2009; 10:233-40.

• Background Reference 02:

  Costa RH, Grayson DR, and Darnell JE Jr. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol. Cell. Biol. 1989; 9:1415-25.

• Background Reference 03:

  Bernardo GM and Keri RA. FOXA1: a transcription factor with parallel functions in development and cancer. Biosci. Rep. 2012; 32:113-30.

• Background Reference 04:

  Robinson JL and Carroll JS. FoxA1 is a key mediator of hormonal response in breast and prostate cancer. Front. Endocrinol 2012; 3:68.

• Other Product Names:

  FOXA1 Antibody: HNF3A, TCF3A, HNF3A, Hepatocyte nuclear factor 3-alpha, Forkhead box protein A1, HNF-3-alpha

• Tested Applications:

  ELISA, WB

• Protein ID:

  24497501

• Physical Properties:

  Liquid