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FOXA1 Antibody

CAT: 0223-7255-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7255-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FOXA1 Antibody: FOXA1 is one of three members of the FOXA family, a subset of the forkhead family of transcription factors which play vital roles in development. It has also been implicated in the development of a number of other organs including the androgen and estrogen regulated tissues of the breast and prostate. FOXA1 modulates the transcriptional activity of nuclear hormone receptors and regulates apoptosis by inhibiting the expression of BCL-2. It is an essential protein for the transcriptional activity of both androgen receptor (AR) and estrogen receptor-α (ER) . FOXA1 plays a pivotal role from early stage cancer through to drug resistant and metastatic disease. FOXA1 is not only an attractive therapeutic target but could potentially function as a novel biomarker.
NCBI Gene ID
3169
Swiss Prot
P55317
Accession Number
NP_004487
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
FOXA1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (86%), Rat: (79%)
Buffer
FOXA1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FOXA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
52 kDa
Fragment
IgG
Specificity
Multiple isoforms of FOXA1 exists as a result of alternative splicing event.
Symbol
FOXA1
NCBI Official Name
Forkhead box A1
NCBI Organism
Homo sapiens
Background Reference 01
Hannenhalli S and Kaestner KH. The evolution of Fox genes and their role in development and disease. Nat. Rev. Genet. 2009; 10:233-40.
Background Reference 02
Costa RH, Grayson DR, and Darnell JE Jr. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol. Cell. Biol. 1989; 9:1415-25.
Background Reference 03
Bernardo GM and Keri RA. FOXA1: a transcription factor with parallel functions in development and cancer. Biosci. Rep. 2012; 32:113-30.
Background Reference 04
Robinson JL and Carroll JS. FoxA1 is a key mediator of hormonal response in breast and prostate cancer. Front. Endocrinol 2012; 3:68.
Other Product Names
FOXA1 Antibody: HNF3A, TCF3A, HNF3A, Hepatocyte nuclear factor 3-alpha, Forkhead box protein A1, HNF-3-alpha
Tested Applications
ELISA, WB
Protein ID
24497501
Physical Properties
Liquid

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