GRIP1 Antibody

• Background :

  GRIP1 Antibody: Glutamate receptors play an important role in neural plasticity, development and degeneration. The glutamate receptor interacting proteins, GRIP1 and GRIP2, members of the PDZ domain-containing protein family, mediate the trafficking and membrane organization of a number of transmembrane proteins. GRIP1 and GRIP2 specifically bind to the AMPA receptor subunits, GluR 2/3 and are involved in the targeting of GluR 2/3 to the synapse. GRIP1 is expressed in early development before the expression of AMPA receptors, while GRIP2 expression parallels that of AMPA receptors during later developmental stages. GRIP1 and GRIP2 may be involved in the induction of cerebellar long-term depression (LTD) .

• NCBI Gene ID :

  23426

• Swiss Prot :

  Q9Y3R0

• Accession Number :

  NP_066973

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  GRIP1 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  GRIP1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  GRIP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment :

  IgG

• Symbol :

  GRIP1

• NCBI Official Name :

  Glutamate receptor interacting protein 1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 1992; 258:597-603.

• Background Reference 02 :

  Dong H, Zhang P, Song I, et al. Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. J. Neurosci. 1999; 19:6930-41.

• Background Reference 03 :

  Mao L, Takamiya K, Thomas G, et al. GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions. Proc. Natl. Acad. Sci. USA 2010; 107:19038-43.

• Background Reference 04 :

  Thomas GM, Hayashi T, Chiu SL, et al. Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking. Neuron 2012; 73:482-96.

• Other Product Names :

  GRIP1 Antibody: GRIP, Glutamate receptor-interacting protein 1, GRIP-1

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  223890252

• Physical Properties :

  Liquid