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IL-17RE Antibody

CAT: 0223-7181-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7181-01Size:0.02 mg
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Background
IL-17RE Antibody: The interleukin 17 receptor E (IL-17RE) shares limited similarity to the receptor of IL-17A, a ubiquitous type I membrane glycoprotein that with IL-17A plays a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RE is the functional receptor of IL-17C and has been suggested to mediate mucosal immunity to infection with intestinal pathogens. IL-17C is produced by epithelia in response to bacterial challenge and binds to a receptor complex formed by IL-17RE and IL-17RA on the epithelial cell surface, thereby regulating the immune function of epithelial cells in an autocrine manner.
NCBI Gene ID
132014
Swiss Prot
Q8NFR9
Accession Number
NP_705616
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
IL-17RE Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1316 - Human Ovary Tissue Lysate
Concentration
1 mg/mL
Buffer
IL-17RE Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-17RE antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 78 kDa
Fragment
IgG
Symbol
IL17RE
NCBI Official Name
Interleukin 17 receptor E
NCBI Organism
Homo sapiens
Background Reference 01
Li TS, Li XN, Chang CJ, et al. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway. Cell Signal. 2006; 18:1287-98.
Background Reference 02
Moseley TA, Haudenschild DR, Rose L, et al. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003; 14:155-74.
Background Reference 03
Song Z, Zhu S, Shi P, et al. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat. Immunol. 2011; 12:1151-8.
Background Reference 04
Ramirez-Carrozzi V, Sambandam A, Luis E, et al. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol. 2011; 12:1159-66
Other Product Names
IL-17RE Antibody: Interleukin-17 receptor E, IL-17 receptor E
Tested Applications
ELISA, WB
Protein ID
301129232
Physical Properties
Liquid

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