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TSPY1S Antibody

CAT: 0223-7123-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7123-01Size:0.02 mg
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Background
TSPY1S Antibody: Testis-specific protein on Y chromosome (TSPY1) is an ampliconic gene on the Y chromosome that has been associated with gonadoblastoma. Recent experiments have shown that in androgen-dependent testicular germ-cell tumors, TSPY1 can repress the androgen-bound androgen receptor (AR), a member of the nuclear steroid hormone receptor family that acts as a ligand-inducible transcription factor, suggesting that TSPY1 is a repressor of cell proliferation in germ-cell tumors and potentially in normal gonadal cells during early development. Two distinct isoforms of TSPY1, TSPY1L and TSPY1S, are known to exist.
NCBI Gene ID
7258
Swiss Prot
Q01534
Accession Number
NP_001184171
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
TSPY1S Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
TSPY1S Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TSPY1S antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
IgG
Specificity
TSPY1S antibody is human and mouse reactive. At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1S
Symbol
TSPY1
NCBI Official Name
Testis specific protein, Y-linked 1
NCBI Organism
Homo sapiens
Background Reference 01
Arnemann J, Jakubiczka S, Thuring S, et al. Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY. Genomics 1991; 11:108-114
Background Reference 02
Lau YF. Gonadoblastoma, testicular and prostate cancers, and the TSPY gene. Am. J. Hum. Genet. 1999; 64:921-7.
Background Reference 03
Akimoto C, Ueda T, Inoue K, et al. Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. Proc. Natl. Acad. Sci. USA 2010; 107:19891-6.
Background Reference 04
Krick R, Jacubiczka S, and Arnemann J. Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes. Gene 2003; 302:11-9.
Other Product Names
TSPY1S Antibody: CT78, TSPY, DYS14, pJA923, Testis-specific Y-encoded protein 1, CT78
Tested Applications
ELISA, WB
Protein ID
308522758
Physical Properties
Liquid

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