FOXH1 Antibody

• Background:

  FOXH1 Antibody: FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.

• NCBI Gene ID:

  8928

• Swiss Prot:

  O75593

• Accession Number:

  NP_003914

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  FOXH1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1304 - Human Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  FOXH1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  FOXH1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  40 kDa

• Fragment:

  IgG

• Specificity:

  FOXH1 antibody is predicted to not cross-react with any other members of the forkhead box family.

• Symbol:

  FOXH1

• Positive Control 2:

  Cat. No. 10-201 - Human Liver Tissue Slide

• NCBI Official Name:

  Forkhead box H1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen X, Weisberg E, Fridmacher V, et al. Smad and FAST-1 in the assembly of activin-responsive factor. Nature 1997; 389:85-9.

• Background Reference 02:

  Zhou S, Zewel L, Lengauer C, et al. Characterization of human FAST-1, a TGF beta and activin signal transducer. Mol. Cell 1998; 2:121-7.

• Background Reference 03:

  Attisano L, Silvestri C, Izzi L, et al. The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signaling. Mol. Cell. Endocrinol. 2001; 180:3-11.

• Other Product Names:

  FOXH1 Antibody: FAST1, FAST-1, FAST1, FAST2, Forkhead box protein H1, Forkhead activin signal transducer 1, Fast-1

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  4503657

• Physical Properties:

  Liquid