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CLAUDIN4 Antibody

CAT: 0223-7025-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7025-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.
NCBI Gene ID
1364
Swiss Prot
O14493
Accession Number
NP_001296
Host
Rabbit
Reactivity
Human
Immunogen
7025
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar CLAUDIN4 expression profile in human cell lines detected by two independent anti-CLAUDIN4 antibodies that recognize different epitopes, 7025 against C-terminus domain and 24-028 against C-terminus domain. CLAUDIN4 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines7025 24-028
Field of Research
Cancer, Cell Cycle
Purification
CLAUDIN4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1219 - MCF7 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%), Mouse (94%) and Rat (88%) .
Buffer
CLAUDIN4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CLAUDIN4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms
Isoform
Human CLAUDIN4 has one isoform (209aa, 22kD) . Mouse CLAUDIN4 has one isoform (210aa, 22kD) and Rat CLAUDIN4 also has one isoform (210aa, 22kD) . 7025 can detect human, mouse and rat.
Symbol
CLDN4
Positive Control 2
Cat. No. 1220 - SK-N-SH Cell Lysate
NCBI Official Name
Claudin 4
NCBI Organism
Homo sapiens
Background Reference 01
Mitic et al. Protein Sci. 2003; 12:218-27.
Background Reference 02
Paperna et al. Genomics 1998; 54:453-9.
Background Reference 03
Morin. Cancer Res. 2005; 65:9603-6.
Other Product Names
CLAUDIN4 Antibody: CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R, CPER, Claudin-4, Clostridium perfringens enterotoxin receptor
Tested Applications
ELISA, WB, IF
Protein ID
4502877
Physical Properties
Liquid

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