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CCDC22 Antibody

CAT: 0223-6933-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6933-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CCDC22 Antibody: CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID) .
NCBI Gene ID
28952
Swiss Prot
O60826
Accession Number
NP_054727
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
CCDC22 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
CCDC22 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CCDC22 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of CCDC22 are known to exist; this antibody will detect the two largest isoforms.
Symbol
CCDC22
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Coiled-coil domain containing 22
NCBI Organism
Homo sapiens
Background Reference 01
Tomsig JL, Snyder SL, and Creutz CE. Identification of targets for calcium signaling through the copine family of proteins. J. Biol. Chem. 2003; 278:10048-54.
Background Reference 02
Mulder J, Bjorling E, Jonasson K, et al. Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. Mol. Cell Prot. 2009; 8:1612-22.
Background Reference 03
Mulder J, Wernerus H, Shi TJ, et al. Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system. Neurosci.2007; 146:1689-703
Background Reference 04
Voineagu I, Huang L, Winden K, et al. CCDC22: a novel candidate gene for syndromic X-linked intellectual disability. Mol. Psych. 2012; 17:4-7.
Other Product Names
CCDC22 Antibody: JM1, CXorf37, JM1, Coiled-coil domain-containing protein 22
Tested Applications
ELISA, WB, IF
Protein ID
7661844
Physical Properties
Liquid

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