ZNF687 Antibody

• Background:

  ZNF687 Antibody: The zinc finger protein 687 (ZNF687) was initially identified as a translocation partner gene with RUNX1 in patients with acute myeloid leukemia (AML) . Little is known of the function of the ZNF687 protein, but it has been shown to weakly interact with the Ring1/Rnf2 RING finger protein member of the Polycomb group of proteins, suggesting it may be involved in the chromatin-modifying complexes essential for embryonic development and stem cell renewal. Other evidence suggests that ZNF687 may be part of a transcriptional network that also includes ZNF592 and ZMYMD8.

• NCBI Gene ID:

  57592

• Swiss Prot:

  Q8N1G0

• Accession Number:

  NP_065883

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  ZNF687 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (82%)

• Buffer:

  ZNF687 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZNF687 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  ZNF687 antibody is human specific. At least three isoforms of ZNF687 are known to exist; this antibody will only detect the largest isoform.

• Symbol:

  ZNF687

• Positive Control 2:

  Cat. No. 17-005 - Jurkat Cell Slide

• NCBI Official Name:

  Zinc finger protein 687

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nguyen TT, Ma LN, Slovak ML, et al. Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTDf2, and ZNF687 in acute myeloid leukemia. Genes Chromo. Cancer 2006; 45:918-32.

• Background Reference 02:

  Sanchez C, Sanchez I, Demmers JA, et al. Proteomics analysis of Ring1/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol. Cell Proteomics 2007; 6:820-34

• Background Reference 03:

  Malovannaya A, Lanz RB, Jung SY, et al. Analysis of the human endogenous coregulator complexome. Cell 2011; 145:787-99.

• Other Product Names:

  ZNF687 Antibody: KIAA1441, Zinc finger protein 687

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  24308227

• Physical Properties:

  Liquid