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RNASET2 Antibody

CAT: 0223-6763-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6763-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RNASET2 Antibody: RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.
NCBI Gene ID
8635
Swiss Prot
O00584
Accession Number
NP_003721
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
RNASET2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1221 - SW480 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (100%)
Buffer
RNASET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RNASET2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
RNASET2
NCBI Official Name
Ribonuclease T2
NCBI Organism
Homo sapiens
Background Reference 01
Acquati F, Morelli C, Cinquetti R, et al. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene 2001; 20:980-8.
Background Reference 02
Campomenosi P, Salis S, Lingqvist C, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochm. Biophys. 2006; 449:17-26
Background Reference 03
Polakowski N, Han H, and Lemasson I. Direct inhibition of RNase T2 expression by the HLTV-1 viral protein Tax. Viruses 2011; 3:1485-500.
Other Product Names
RNASET2 Antibody: RNASE6PL, bA514O12.3, RNASE6PL, Ribonuclease T2, Ribonuclease 6
Tested Applications
ELISA, WB, ICC, IF
Protein ID
5231228
Physical Properties
Liquid

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