TGM5 Antibody

• Background:

  TGM5 Antibody: Transglutaminases (TGM) are a family of structurally and functionally related Ca2+-dependent enzymes (TGases) that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. TGases influence numerous biological processes, including blood coagulation, cell differentiation, fertilization and apoptosis. TGM5 belongs to the transglutaminase superfamily and catalyzes the cross-linking of proteins between glutamine and lysine residues, often resulting in stabilization of protein assemblies. TGM5 is also expressed in the human hair follicle. Defects in TGM5 are associated with acral peeling skin syndrome.

• NCBI Gene ID:

  9333

• Swiss Prot:

  O43548

• Accession Number:

  NP_963925

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  TGM5 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1461 - Rat Heart Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TGM5 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TGM5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  TGM5 antibody is predicted to not cross-react with other TGase protein family members. Multiple isoforms of TGM5 are known to exist.

• Symbol:

  TGM5

• NCBI Official Name:

  Transglutaminase 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ueki S, et al. Dual functions of transglutaminase in novel cell adhesion. J. Cell Sci. 1996; 109:2727-35.

• Background Reference 02:

  Candi E, Oddi S, Terrinoni A, et al. Transglutaminase 5 cross-links loricrin, involicrin, and small proline-rich proteins in vitro. J. Biol. Chem. 2001; 276:35014-23.

• Background Reference 03:

  Thibaut S, Candi E, Pietroni V, et al. Transglutaminase 5 expression in human hair follicle. J. Invest. Dermatol. 2005; 125:581-5

• Background Reference 04:

  Cassidy AJ, van Steensel MA, Steijlen PM, et al. A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome. Am. J. Hum. Genet. 2005; 77:909-17.

• Other Product Names:

  TGM5 Antibody: TGX, TGM6, TGMX, TGASE5, TGASEX, Protein-glutamine gamma-glutamyltransferase 5, Transglutaminase X, TGX

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  94981556

• Physical Properties:

  Liquid