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TMEM59L Antibody

CAT: 0223-6435-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6435-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.
NCBI Gene ID
25789
Swiss Prot
Q9UK28
Accession Number
NP_036241
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
TMEM59L Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1461 - Rat Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (89%)
Buffer
TMEM59L Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TMEM59L antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.
Symbol
TMEM59L
NCBI Official Name
Transmembrane protein 59-like
NCBI Organism
Homo sapiens
Background Reference 01
Schö bel S, Neumann S, Seed B, et al. Expression cloning screen for modifiers of amyloid precursor protein shedding. Int. J. Dev. Neurosci. 2006; 24:141-8.
Background Reference 02
Schö bel S, Neumann S, Hertweck M, et al. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 2008; 283:14257-68.
Background Reference 03
Elson GC, de Coignac AB, Aubry JP, et al. BSMAP, a novel protein expressed specifically in the brain whose gene is localized on chromosome 19p12. Biochem. Biophys. Res. Commun. 1999; 264:55-62.
Background Reference 04
Ullrich S, Münch A, Neumann S, et al. The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein. J. Biol. Chem. 2010; 285:20664-74.
Other Product Names
TMEM59L Antibody: BSMAP, C19orf4, BSMAP, Transmembrane protein 59-like, Brain-specific membrane-anchored protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
6912274
Physical Properties
Liquid

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