Products for Research Use Only
RegisterLogin

LIF Antibody

CAT: 0223-6245-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-6245-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
LIF Antibody: LIF is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. LIF was initially recognized by its ability to induce terminal differentiation of myeloid leukemic cells. It is a member of the IL-6 cytokine superfamily and can be highly glycosylated. LIF signaling is transduced through the LIF-R/gp130 receptor complex, leading to the phosphorylation and activation of the JAK/STAT pathway. Recent evidence shows that LIF inhibits cardiomyogenesis in embryonic stem cells via STAT3 activation.
NCBI Gene ID
3976
Swiss Prot
P15018
Accession Number
NP_002300
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
6245
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 3) : Anit-LIF antibodies (6245) detected human LIF recombinant protein at different concentrations. Recombinant Protein Test6245
Field of Research
Stem Cell
Purification
LIF Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
LIF Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
LIF antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of LIF are known to exist.
Isoform
Human LIF has 2 isoforms, including isoform 1 (202aa, 22kD) and isoform 2 (88aa, 9.6kD) . Mouse LIF has 1 isoform (203aa, 22.3kD and Rat LIF also has 1 isoform (202aa, 22.1kD) . 6245 can detect human isoform1 as well as mouse and rat LIF.
Symbol
LIF
Positive Control 2
Cat. No. 17-201 - 3T3/BALB Cell Slide
NCBI Official Name
Leukemia inhibitory factor
NCBI Organism
Homo sapiens
Background Reference 01
Trouillas et al. Cytokine Netw. 2009; 20:51-62.
Background Reference 02
Hilton et al. Anal. Biochem. 1988; 173:359-67.
Background Reference 03
Schemlzer et al. Protein Expr. Purif. 1990; 1:54-62.
Other Product Names
LIF Antibody: CDF, DIA, HILDA, MLPLI, Leukemia inhibitory factor, Differentiation-stimulating factor, LIF
Tested Applications
ELISA, WB, IF
Protein ID
4504991
Physical Properties
Liquid

Related Products

CatalogName
6245PLIF Peptide
43-200PLIF Peptide
91-575LIF Recombinant Protein
97-011LIF Recombinant Protein
40-682LIF Recombinant Protein
40-684LIF Recombinant Protein
91-014LIF Recombinant Protein
90-277LIF Recombinant Protein
96-519LIF Recombinant Protein (HEK293 Expressed)
40-750LIF Recombinant Protein (Animal Free)

Alternative Products

CatalogName
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody
MBS850197-01Antibody to IGFBP2 Antibody
DF8746-01ASAP1 antibody Antibody
E36403ZNF98 Antibody Antibody
GWB-250026Lck antibody Antibody
E8M1007-4HSP60 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
GWB-5C6547MAD1L1 antibody [9B10] Antibody

Popular Products