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VPS39 Antibody

CAT: 0223-6183-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6183-01Size:0.02 mg
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Background
VPS39 Antibody: VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6.5.
NCBI Gene ID
23339
Swiss Prot
Q96JC1
Accession Number
AAQ05978
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
VPS39 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
VPS39 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VPS39 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least four isoforms of VPS39 are known to exist; this antibody will detect all four. VPS39 antibody is predicted not to cross-react with TRAP1.
Symbol
VPS39
NCBI Official Name
Vacuolar protein sorting 39 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Nakamura N, Hirata A, Ohsumi Y, et al. Vam2/Vps41p and Vam6/Vps39p are components of a protein complex on the vacuolar membranes and involved in the vacuolar assembly in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 1997; 272:11344-9.
Background Reference 02
Caplan S, Hartnell LM, Aguilar RC, et al. Human Vam6p promotes lysosome clustering and fusion in vivo. J. Cell Biol. 2001; 154:109-22.
Background Reference 03
Felici A, Wurthner JU, Parks WT, et al. TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J. 2003; 22:4465-77.
Background Reference 04
Messler S, Kropp S, Episkopou V, et al. The TGF-b signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development. Immunobiology 2011; 216:343-50.
Other Product Names
VPS39 Antibody: TLP, VAM6, hVam6p, KIAA0770, TLP, TRAP1-like protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
54234024
Physical Properties
Liquid

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