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ZBTB7A Antibody

CAT: 0223-6127-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6127-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ZBTB7A Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells.
NCBI Gene ID
51341
Swiss Prot
O95365
Accession Number
AAH84568
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ZBTB7A Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1316 - Human Ovary Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Rat: (94%), Chicken: (88%)
Buffer
ZBTB7A Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZBTB7A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms of ZBTB7A are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.
Symbol
ZBTB7A
Positive Control 2
Cat. No. 11-201 - Human Ovary Tissue Slide
NCBI Official Name
Zinc finger and BTB domain containing 7A
NCBI Organism
Homo sapiens
Background Reference 01
Filion GJP, Zhenilo S, Salozhin S, et al. A family of zinc finger proteins that bind methylated DNA and repress transcription. Mol. Cell. Biol.2006; 26:169-81.
Background Reference 02
Davies JM, Hawe N, Kabarowski J, et al. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene1999; 18:365-75.
Background Reference 03
Pendergrast PS, Wang C, Hernandez N, et al. FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles. Mol. Cell. Biol.2002; 13:915-29.
Background Reference 04
Qu H, Qu D, Chen F, et al. ZBTB7 overexpression contributes to malignancy in breast cancer. Cancer Invest.2010; 28:672-8.
Other Product Names
ZBTB7A Antibody: LRF, FBI1, FBI-1, ZBTB7, ZNF857A, pokemon, LRF, Zinc finger and BTB domain-containing protein 7A, Factor binding IST protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7705375
Physical Properties
Liquid

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