TFF3 Antibody

• Background:

  TFF3 Antibody: Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa.

• NCBI Gene ID:

  7033

• Swiss Prot:

  Q07654

• Accession Number:

  NP_003217

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  TFF3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1320 - Human Colon Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (81%), Pig: (81%)

• Buffer:

  TFF3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TFF3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  TFF3 antibody is predicted to not cross-react with other TFF family members.

• Symbol:

  TFF3

• Positive Control 2:

  Cat. No. 11-801 - Human Small Intestine Tissue Slide

• NCBI Official Name:

  Trefoil factor 3 (intestinal)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Podolsky DK, Lynch-Devaney K, Stow JL, et al. Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. J. Biol. Chem. 1993; 268:6694-702.

• Background Reference 02:

  Gott P, Beck S, Machado JC, et al. Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. Eur. J. Hum. Genet. 1996; 4:308-15.

• Background Reference 03:

  Hernandez C, Santamatilde E, McCreath KJ, et al. Induction of trefoil factor TFF1, TFF2 and TFF3 by hypoxia is mediated by hypoxia inducible factor-1: implications for gastric mucosal healing. Br. J. Pharmacol. 2009; 156:262-72.

• Background Reference 04:

  Thim L. Trefoil peptides: from structure to function. Cell Mol. Life Sci. 1997; 53:888-903.

• Other Product Names:

  TFF3 Antibody: ITF, P1B, TFI, ITF, Trefoil factor 3, Intestinal trefoil factor, hITF

• Tested Applications:

  ELISA, WB, IHC-P, ICC, IF

• Protein ID:

  119629977

• Physical Properties:

  Liquid