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ZNF521 Antibody

CAT: 0223-6065-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6065-01Size:0.02 mg
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Background
ZNF521 Antibody: The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.
NCBI Gene ID
25925
Swiss Prot
Q96K83
Accession Number
NP_056276
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
ZNF521 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 10-401 - Human Kidney Tissue Slide
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (100%)
Buffer
ZNF521 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ZNF521 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
ZNF521 antibody is human specific.
Symbol
ZNF521
NCBI Official Name
Zinc finger protein 521
NCBI Organism
Homo sapiens
Background Reference 01
Warming S, Liu P, Suzuki T, et al. Evi3, a common retroviral integration site in murine B-cell lymphoma, encodes a EBFAZ-related Kruppel-like zinc finger protein. Blood 2003; 101:1934-40.
Background Reference 02
Matsubara E, Sakai I, Yamanouchi J, et al. The role of zinc finger protein 521/early hematopoietic zinc finger protein in erythroid cell differentiation. J. Biol. Chem. 2009; 284:3480-7.
Background Reference 03
Wu M, Hesse E, Morvan F, et al. Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo. Bone 2009; 44:528-36.
Background Reference 04
Hesse E, Saito H, Kiviranta R, et al. Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. J. Cell Biol. 2010; 191:1271-83.
Other Product Names
ZNF521 Antibody: EHZF, Evi3, EHZF, LIP3, Zinc finger protein 521, Early hematopoietic zinc finger protein
Tested Applications
ELISA, IHC-P
Protein ID
24308069
Physical Properties
Liquid

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