PIWI-L3 Antibody

• Background:

  PIWI-L3 Antibody: PIWI-L3 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. Recent studies have shown that overexpression of PIWI-L3 (as well as other PIWI-like proteins) are potential biomarkers for astrocytic glioma, meningioma, and other cancers.

• NCBI Gene ID:

  440822

• Swiss Prot:

  Q7Z3Z3

• Accession Number:

  NP_001008496

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  PIWI-L3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1282 - 3T3 (NIH) Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PIWI-L3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PIWI-L3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  PIWIL3

• Positive Control 2:

  Cat. No. 17-201 - 3T3/BALB Cell Slide

• NCBI Official Name:

  Piwi-like 3 (Drosophila)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sasaki T, Shiohama A, Minoshima S, et al. Identification of eight members of the Argonaute family in the human genome small star, filled. Genomics2003; 323-30.

• Background Reference 02:

  Thomson T and Lin H. The biogenesis and function PIWI proteins and piRNAs: progress and prospect. Annu. Rev. Cell Dev. Biol.2009; 25:355-76.

• Background Reference 03:

  Wang XL, Chen XM, Gao HJ, et al. Preparation and distribution of polyclonal antibodies against human PIWIL3 protein in tumor tissues. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008; 24:714-6.

• Background Reference 04:

  Li L, Yu C, Gao H, et al. Argonaute proteins: potential biomarkers for human colon cancer. BMC Cancer2010; 10:38.

• Other Product Names:

  PIWI-L3 Antibody: HIWI3, Piwi-like protein 3

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  153792298

• Physical Properties:

  Liquid