TRIP6 Antibody

• Background:

  TRIP6 Antibody: TRIP6 (Thyroid receptor interacting protein 6) is a zyxin-related focal adhesion molecule involved in cell motility and antiapoptotic responses. TRIP6 is predominantly expressed in kidney, liver and lung. It has three LIM domains, a PDZ-binding motif, a Crk SH2-binding motif and/or other protein interacting domains. TRIP6 regulates NF-κ B activation and interacts with RICK and TRAF2, proteins that are involved in TNF signaling. TRIP6 antagonizes Fas-induced apoptosis and promotes Fas-mediated cell migration in apoptosis-resistant glioma cells via Src-dependent phosphorylation of TRIP6 at Tyr-55.

• NCBI Gene ID:

  7205

• Swiss Prot:

  Q15654

• Accession Number:

  NP_003293

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  TRIP6 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1202 - A431 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (86%)

• Buffer:

  TRIP6 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TRIP6 antibody can be stored at 4μ C for three months and -20μ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  TRIP6

• Positive Control 2:

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name:

  Thyroid hormone receptor interactor 6

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Murthy KK, Clark K, Fortin Y, et al. ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. J. Biol. Chem.1999; 274:20679-87.

• Background Reference 02:

  Kassel O, Schneider S, Heilbock C, et al. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB regulated promoters. Genes Dev.2004; 18:2518-2528.

• Background Reference 03:

  Lai YJ, Chen CS, Lin WJ, et al. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol. Cell. Biol.2005; 25:5859-5868.

• Background Reference 04:

  Li L, Bin LH, Li F, et al. TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J. Cell. Sci.2005; 118:555-563.

• Other Product Names:

  TRIP6 Antibody: OIP1, OIP-1, ZRP-1, TRIP-6, TRIP6i2, OIP1, Thyroid receptor-interacting protein 6, Opa-interacting protein 1, TR-interacting protein 6

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  91208423

• Physical Properties:

  Liquid