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TRIP6 Antibody

CAT: 0223-6001-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6001-01Size:0.02 mg
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Background
TRIP6 Antibody: TRIP6 (Thyroid receptor interacting protein 6) is a zyxin-related focal adhesion molecule involved in cell motility and antiapoptotic responses. TRIP6 is predominantly expressed in kidney, liver and lung. It has three LIM domains, a PDZ-binding motif, a Crk SH2-binding motif and/or other protein interacting domains. TRIP6 regulates NF-κ B activation and interacts with RICK and TRAF2, proteins that are involved in TNF signaling. TRIP6 antagonizes Fas-induced apoptosis and promotes Fas-mediated cell migration in apoptosis-resistant glioma cells via Src-dependent phosphorylation of TRIP6 at Tyr-55.
NCBI Gene ID
7205
Swiss Prot
Q15654
Accession Number
NP_003293
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
TRIP6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (86%)
Buffer
TRIP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TRIP6 antibody can be stored at 4μ C for three months and -20μ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TRIP6
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Thyroid hormone receptor interactor 6
NCBI Organism
Homo sapiens
Background Reference 01
Murthy KK, Clark K, Fortin Y, et al. ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. J. Biol. Chem.1999; 274:20679-87.
Background Reference 02
Kassel O, Schneider S, Heilbock C, et al. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB regulated promoters. Genes Dev.2004; 18:2518-2528.
Background Reference 03
Lai YJ, Chen CS, Lin WJ, et al. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Mol. Cell. Biol.2005; 25:5859-5868.
Background Reference 04
Li L, Bin LH, Li F, et al. TRIP6 is a RIP2-associated common signaling component of multiple NF-kB activation pathways. J. Cell. Sci.2005; 118:555-563.
Other Product Names
TRIP6 Antibody: OIP1, OIP-1, ZRP-1, TRIP-6, TRIP6i2, OIP1, Thyroid receptor-interacting protein 6, Opa-interacting protein 1, TR-interacting protein 6
Tested Applications
ELISA, WB, ICC, IF
Protein ID
91208423
Physical Properties
Liquid

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