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NALP6 Antibody

CAT: 0223-5961-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5961-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NALP6 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-κ B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
NCBI Gene ID
171389
Swiss Prot
P59044
Accession Number
NP_612202
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
NALP6 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (92%), Rat: (92%)
Buffer
NALP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NALP6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NLRP6
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
NLR family, pyrin domain containing 6
NCBI Organism
Homo sapiens
Background Reference 01
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Background Reference 02
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Background Reference 03
Grenier JM, Wang L, Manji GA, et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett.2002; 530:73-8.
Other Product Names
NALP6 Antibody: AVR, NAVR, PAN3, NALP6, PYPAF5, CLR11.4, NAVR/AVR, NACHT, LRR and PYD domains-containing protein 6, PYRIN-containing APAF1-like protein 5
Tested Applications
ELISA, WB, IF
Protein ID
21264320
Physical Properties
Liquid

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