Products for Research Use Only
RegisterLogin

NALP4 Antibody

CAT: 0223-5957-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5957-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
NALP4 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-κ B induction by TNF-α and IL-1β , suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-κ B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-κ B activity.
NCBI Gene ID
147945
Swiss Prot
Q96MN2
Accession Number
AAL35293
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
NALP4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Buffer
NALP4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NALP4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
NLRP4
NCBI Official Name
NLR family, pyrin domain containing 4
NCBI Organism
Homo sapiens
Background Reference 01
Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
Background Reference 02
Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
Background Reference 03
Fiortino L, Stehlik C, Oliveira V, et al. A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. J. Biol. Chem.2002; 277:35333-40.
Other Product Names
NALP4 Antibody: CT58, PAN2, RNH2, NALP4, PYPAF4, CLR19.5, NACHT, LRR and PYD domains-containing protein 4, PAAD and NACHT-containing protein 2, CT58
Tested Applications
ELISA, WB
Protein ID
17064172
Physical Properties
Liquid

Related Products

CatalogName
5957PNALP4 Peptide
5965-01mgNALP8 Antibody
5961-002mgNALP6 Antibody
3037-01mgNALP1 Antibody
5959-01NALP5 Antibody
5975-01mgNALP14 Antibody
5963-01mgNALP7 Antibody
5965-002mgNALP8 Antibody
5959-01mgNALP5 Antibody
5965-01NALP8 Antibody

Alternative Products

CatalogName
MBS9409831-01NALP4 Antibody
MBS9238104-01NALP4 Polyclonal Antibody
APR06666GPolyclonal NALP4 Antibody
NBP3-17191-25ulRabbit Polyclonal NALP4 Antibody
BT-AP03758-01NALP4 Rabbit Polyclonal Antibody
SL25219R-01Rabbit Anti-NALP4 antibody
TMAB-09217-01Anti-NALP4 Polyclonal Antibody
GTR18402572-01NALP4 rabbit pAb Antibody
A08477Anti-NALP4 NLRP4 Antibody
GTR18994979NALP4 Antibody Blocking Peptide

Popular Products