Products for Research Use Only
RegisterLogin

ALKBH2 Antibody

CAT: 0223-5871-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5871-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
ALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
NCBI Gene ID
121642
Swiss Prot
Q6NS38
Accession Number
NP_001138847
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
ALKBH2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Buffer
ALKBH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ALKBH2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ALKBH2
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
AlkB, alkylation repair homolog 2 (E. coli)
NCBI Organism
Homo sapiens
Background Reference 01
Duncan T, Trewick SC, Koivisto P, et al. Reversal of DNA alkylation damage by two human dioxygenases. Proc. Natl. Acad. Sci. USA2002; 99:16660-5.
Background Reference 02
Cetica V, Genitori L, Giunti L, et al. Pediatric brain tumors: mutations of two dioxygenases (hABH2 and hABH3) that directly repair alkylation damage. J. Neurooncol.2009; 195-201.
Background Reference 03
Chen H, Giri NC, Zhang R, et al. Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J. Biol. Chem.2010; 285:7374-83.
Background Reference 04
Lee SY, Luk SK, Chuang CP, et al. TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy. Br. J. Cancer2010; 103:362-9.
Other Product Names
ALKBH2 Antibody: ABH2, ABH2, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, Alkylated DNA repair protein alkB homolog 2
Tested Applications
ELISA, WB, IHC-P
Protein ID
224451107
Physical Properties
Liquid

Related Products

CatalogName
5871PALKBH2 Peptide
29-495ALKBH8 Antibody
29-494ALKBH8 Antibody
56-638ALKBH4 Antibody
23-201ALKBH4 Antibody
18-607ALKBH7 Antibody
27-021ALKBH3 Antibody
55-757ALKBH6 Antibody
22-736ALKBH8 Antibody
19-870ALKBH3 Antibody

Alternative Products

CatalogName
70R-4415ALKBH2 antibody

Popular Products