SCRN3 Antibody

• Background:

  SCRN3 Antibody: SCRN3 is a member of the secernin family of proteins which includes the homologous SCRN1, a protein that was first identified as being involved in the regulation of exocytosis from peritoneal mast cells. Little is known of SCRN3, but studies have shown that SCRN1 may possess epitopes that function as tumor-associated antigens in gastric cancers and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN3 may also be involved in protein secretion or the regulation of cell growth.

• NCBI Gene ID:

  79634

• Swiss Prot:

  Q0VDG4

• Accession Number:

  AAI19685

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  SCRN3 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1311 - Human Breast Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%)

• Buffer:

  SCRN3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SCRN3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  SCRN3

• Positive Control 2:

  Cat. No. 17-010 - HEK293 Cell Slide

• NCBI Official Name:

  Secernin 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Way G, Morrice N, Smythe C, et al. Purification and identification of Secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Mol. Biol. Cell2002; 13:3344-54.

• Background Reference 02:

  Suda T, Tsunoda T, Uchida N, et al. Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. Cancer Sci.2006; 97:411-9.

• Background Reference 03:

  Miyoshi N, Ishii H, Mimori K, et al. SCRN1 is a novel marker for prognosis in colorectal cancer. J. Surg. Oncol.2010; 101:156-9.

• Other Product Names:

  SCRN3 Antibody: SES3, Secernin-3

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  111601409

• Physical Properties:

  Liquid