FOXO4 Antibody

• Background :

  FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.

• NCBI Gene ID :

  4303

• Swiss Prot :

  P98177

• Accession Number :

  NP_005929

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  FOXO4 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  FOXO4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  FOXO4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  FOXO4

• Positive Control 2 :

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name :

  Forkhead box O4

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Anderson MJ, Viars CS, Czekay S, et al. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics1998; 47:187-99.

• Background Reference 02 :

  Greer EL and Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene2005; 24:7410-25.

• Background Reference 03 :

  Manning BD and Cantley LC. AKT/PKB signaling: navigating downstream. Cell2007; 129:1261-74.

• Background Reference 04 :

  Essers MA, Weijzen S, de Vries-Smits AM, et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J.2004; 23:4802-12.

• Other Product Names :

  FOXO4 Antibody: AFX, AFX1, MLLT7, AFX, Forkhead box protein O4, Fork head domain transcription factor AFX1

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  103472003

• Physical Properties :

  Liquid