FOXO1 Antibody

• Background :

  FOXO1 Antibody: FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2) . Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.

• NCBI Gene ID :

  2308

• Swiss Prot :

  Q12778

• Accession Number :

  NP_002006

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Autophagy

• Purification :

  FOXO1 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (100%)

• Buffer :

  FOXO1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  FOXO1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  FOXO1

• Positive Control 2 :

  Cat. No. 17-001 - HeLa Cell Slide

• NCBI Official Name :

  Forkhead box O1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Anderson MJ, Viars CS, Czekay S, et al. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics1998; 47:187-99.

• Background Reference 02 :

  Greer EL and Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene2005; 24:7410-25.

• Background Reference 03 :

  Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell1999; 96:857-68.

• Background Reference 04 :

  Linardic CM. PAX3-FOXO1 fusion gene in rhabdomyosarcoma. Cancer Lett.2008; 270:10-8.

• Other Product Names :

  FOXO1 Antibody: FKH1, FKHR, FOXO1A, Forkhead box protein O1, Forkhead box protein O1A

• Tested Applications :

  ELISA, WB, ICC, IF

• Protein ID :

  9257222

• Physical Properties :

  Liquid