ZSCAN4 Antibody

• Background:

  ZSCAN4 Antibody: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.

• NCBI Gene ID:

  201516

• Swiss Prot:

  Q8NAM6

• Accession Number:

  NP_689890.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  ZSCAN4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1402 - Mouse Lung Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (81%), Chicken: (86%)

• Buffer:

  ZSCAN4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ZSCAN4 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  ZSCAN4

• NCBI Official Name:

  Zinc finger and SCAN domain containing 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hamatani T, Carter MG, Sharov AA, et al. Dynamics of global gene expression changes during mouse preimplantation development. Dev. Cell 2004; 6:117-131.

• Background Reference 02:

  Falco G, Lee SL, Stanghellini I, et al. Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev. Biol. 2007; 307:539-50.

• Background Reference 03:

  Zalzman M, Falco G, Sharova LV, et al. Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature 2010; 464:858-63.

• Other Product Names:

  ZSCAN4 Antibody: ZNF494, ZNF494, Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  22749365

• Physical Properties:

  Liquid