REEP4 Antibody

• Background:

  REEP4 Antibody: Mammalian odorant receptors require accessory proteins such as RTP1 and RTP2 for functional cell surface expression. Receptor expression-enhancing protein (REEP) family members are transmembrane proteins which interact with odorant receptor proteins and may enhance the odorant receptor responses to odorants. Recently studies have shown other chemosensory receptors such as bitter taste receptors are also influenced by RTP and REEP family members. In studies in Xenopus RNAi to reduce REEP4 levels, embryos showed a slightly kinked body axis and were paralyzed. Further analysis revealed downregulated levels of several neural and muscle markers, suggesting the REEP4 may play a role in the maintenance of both the nervous system and musculature.

• NCBI Gene ID:

  80346

• Swiss Prot:

  Q9H6H4

• Accession Number:

  EAW63714

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  REEP4 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1302 - Human Lung Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  REEP4 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  REEP4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  REEP4

• NCBI Official Name:

  Receptor accessory protein 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Saito H, Kubota M, Roberts RW, et al. RTP family members induce functional expression of mammalian odorant receptors. Cell2004; 119:679-91.

• Background Reference 02:

  Behrens M, Bartelt J, Reichling et al. Members of RTP and REEP gene families influence functional bitter taste receptor expression. J. Biol. Chem.2006; 281:20650-9.

• Background Reference 03:

  Argasinska J, Rana AA, Gilchrist MJ, et al. Loss of REEP4 causes paralysis of the Xenopus embryo. Int. J. Dev. Biol.2009; 52:37-43.

• Other Product Names:

  REEP4 Antibody: PP432, C8orf20, PP432, Receptor expression-enhancing protein 4

• Tested Applications:

  ELISA, WB

• Protein ID:

  119584118

• Physical Properties:

  Liquid