Products for Research Use Only
RegisterLogin

PRDM16 Antibody

CAT: 0223-5555-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-5555-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
PRDM16 Antibody: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t (1;3) (p36; q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) . This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t (1:3) (p36, q21) -positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.
NCBI Gene ID
63976
Swiss Prot
Q9HAZ2
Accession Number
CAH71530
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
PRDM16 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Buffer
PRDM16 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PRDM16 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
PRDM16
NCBI Official Name
PR domain containing 16
NCBI Organism
Homo sapiens
Background Reference 01
Mochizuki N, Shimizu S, Nagasawa T, et al. A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t (1;3) (p36; q21) -positive leukemia cells. Blood2000; 96:3209-14.
Background Reference 02
Morishita K. Leukemogenesis of the EVI1/MEL1 gene family. Int. J. Hematol.2007; 85:279-86.
Background Reference 03
Warner DR, Horn KH, Mudd L, et al. PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. Biochim. Biophys. Acta2007; 1773:814-20.
Background Reference 04
Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature2008; 454:961-7.
Other Product Names
PRDM16 Antibody: MEL1, LVNC8, PFM13, CMD1LL, KIAA1675, MEL1, PR domain zinc finger protein 16, PR domain-containing protein 16
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
55665817
Physical Properties
Liquid

Related Products

CatalogName
5555PPRDM16 Peptide
46-216PPRDM16 Peptide
45-121PRDM10 Antibody
22-270PRDM14 Antibody
15-914PRDM10 Antibody
15-130PRDM14 Antibody
27-812PRDM14 Antibody
43-186PRDM14 Antibody
25-526PRDM13 Antibody
19-719PRDM14 Antibody

Alternative Products

CatalogName
DF13303-01PRDM16 Antibody

Popular Products