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RHBDD2 Antibody

CAT: 0223-5527-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-5527-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RHBDD2 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.
NCBI Gene ID
57414
Swiss Prot
Q6NTF9
Accession Number
NP_001035546
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
RHBDD2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1462 - Rat Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
RHBDD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RHBDD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
RHBDD2
NCBI Official Name
Rhomboid domain containing 2
NCBI Organism
Homo sapiens
Background Reference 01
Koonin EV, Makarova KS, Rogozin IB, et al. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple horizontal gene transfers. Genome Biol.2003; 4:R19.
Background Reference 02
Abba MC, Sun H, Hawkins KA, et al. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Mol. Cancer Res.2007; 5:881-90.
Background Reference 03
Abba MC, Lacunza E, Nunez MI, et al. Rhomboid domain containing 2 (RHBDD2) : a novel cancer-related gene over-expressed in breast cancer. Biochim. Biophys. Acta2009; 1792:988-97.
Background Reference 04
Wang Y, Guan X, Fok KL, et al. A novel member of the rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cell Mol. Life Sci.2008; 65:3822-9.
Other Product Names
RHBDD2 Antibody: NPD007, RHBDL7, Rhomboid domain-containing protein 2
Tested Applications
ELISA, WB, IF
Protein ID
94818790
Physical Properties
Liquid

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