RHBDD2 Antibody

• Background:

  RHBDD2 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.

• NCBI Gene ID:

  57414

• Swiss Prot:

  Q6NTF9

• Accession Number:

  NP_001035546

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  RHBDD2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1462 - Rat Lung Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  RHBDD2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  RHBDD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  RHBDD2

• NCBI Official Name:

  Rhomboid domain containing 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Koonin EV, Makarova KS, Rogozin IB, et al. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple horizontal gene transfers. Genome Biol.2003; 4:R19.

• Background Reference 02:

  Abba MC, Sun H, Hawkins KA, et al. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Mol. Cancer Res.2007; 5:881-90.

• Background Reference 03:

  Abba MC, Lacunza E, Nunez MI, et al. Rhomboid domain containing 2 (RHBDD2) : a novel cancer-related gene over-expressed in breast cancer. Biochim. Biophys. Acta2009; 1792:988-97.

• Background Reference 04:

  Wang Y, Guan X, Fok KL, et al. A novel member of the rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cell Mol. Life Sci.2008; 65:3822-9.

• Other Product Names:

  RHBDD2 Antibody: NPD007, RHBDL7, Rhomboid domain-containing protein 2

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  94818790

• Physical Properties:

  Liquid