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TMEM38B Antibody

CAT: 0223-5523-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5523-01Size:0.02 mg
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Background
TMEM38B Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
NCBI Gene ID
55151
Swiss Prot
Q9NVV0
Accession Number
NP_060582
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
TMEM38B Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1471 - Rat Thymus Tissue Lysate
Concentration
1 mg/mL
Buffer
TMEM38B Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TMEM38B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
TMEM38B
NCBI Official Name
Transmembrane protein 38B
NCBI Organism
Homo sapiens
Background Reference 01
Yazawa M, Ferrante C, Feng J, et al. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature2007; 448:78-82.
Background Reference 02
Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca (2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther.2009; 121:265-72.
Background Reference 03
Yamakazi D, Yamakazi T, and Takeshima H. New molecular components supporting ryanodine receptor-mediated Ca (2+) release: roles of junctophilin and TRIC channel in embryonic cardiocytes. Pharmacol. Ther.2009; 121:265-72.
Other Product Names
TMEM38B Antibody: OI14, TRICB, TRIC-B, C9orf87, D4Ertd89e, bA219P18.1, Trimeric intracellular cation channel type B, Transmembrane protein 38B
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
8922461
Physical Properties
Liquid

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