SLAIN2 Antibody

• Background:

  SLAIN2 Antibody: SLAIN2 is closely related to SLAIN1, a novel stem cell protein that is expressed at the stem cell and epiblast stages. Unlike SLAIN1, SLAIN2 is widely expressed and is thought to play a role in regulating microtubule (MT) growth and organization. SLAIN2 binds to end-binding proteins (EBs), cytoplasmic linker proteins (CLIPs) such as CLIP170, CLIP-associated proteins, and interacts with the MT polymerase ch-TOG. Depletion of SLAIN2 using RNAi led to disorganization of the radial MT array, indicating its importance in the regulation of MT growth and organization.

• NCBI Gene ID:

  57606

• Swiss Prot:

  Q9P270

• Accession Number:

  AAH40993

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  SLAIN2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 11-701 - Human Testis Tissue Slide

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (93%)

• Buffer:

  SLAIN2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SLAIN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  IgG

• Specificity:

  SLAIN2 antibody is predicted not to cross-react with SLAIN1.

• Symbol:

  SLAIN2

• NCBI Official Name:

  SLAIN motif family, member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hirst CE, Ng ES, Azzola L, et al. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. Dev. Biol. 2006; 293:90-103.

• Background Reference 02:

  Van der Vaart B, Manatschal C, Grigoriev I, et al. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. J. Cell Biol. 2011; 193:1083-99.

• Other Product Names:

  SLAIN2 Antibody: KIAA1458, KIAA1458, SLAIN motif-containing protein 2

• Tested Applications:

  ELISA, IHC-P

• Protein ID:

  26454712

• Physical Properties:

  Liquid