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JMJD1A Antibody

CAT: 0223-5365-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5365-01Size:0.02 mg
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Background
JMJD1A Antibody: The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintenance of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.
NCBI Gene ID
55818
Swiss Prot
Q9Y4C1
Accession Number
NP_060903
Host
Rabbit
Reactivity
Human, Rat
Immunogen
5365
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 2) shows similar JMJD1A expression profile in human cell lines detected by two independent anti-JMJD1A antibodies that recognize different epitopes, 5365 against N-terminus domain and 5367 against central domain. JMJD1A proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines5365 5367
Field of Research
Stem Cell
Purification
JMJD1A Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (94%), Chicken: (87%)
Buffer
JMJD1A Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
JMJD1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody will not cross-react with JMJD1B or JMJD1C.
Isoform
Human JMJD1A has one isoform (1321aa, 147kD) . Mouse JMJD1A has 2 isoforms, including isoform 1 (1323aa, 148kD) and isoform 2 (831aa, 94kD) . Rat JMJD1A has one isoform (1323aa, 148kD) . 5365 can detect human, mouse and rat.
Symbol
KDM3A
Positive Control 2
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 3
Cat. No. 1219 - MCF7 Cell Lysate
NCBI Official Name
Lysine (K) -specific demethylase 3A
NCBI Organism
Homo sapiens
Background Reference 01
Hoog et al. Mol. Reprod. Dev.1991; 30:173-81.
Background Reference 02
Sar et al. Cell Tissue Res.2009; 337:223-34.
Background Reference 03
Yamane et al. Cell. 2006; 125:483-95.
Background Reference 04
Knebel et al. J. Cell Biochem.2006; 99:319-29.
Other Product Names
JMJD1A Antibody: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, TSGA, Lysine-specific demethylase 3A, JmjC domain-containing histone demethylation protein 2A
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
20357522
Physical Properties
Liquid

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