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IRGC Antibody

CAT: 0223-5295-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5295-01Size:0.02 mg
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Background
IRGC Antibody: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
NCBI Gene ID
56269
Swiss Prot
Q6NXR0
Accession Number
NP_062558
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
IRGC Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
IRGC Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IRGC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.
Symbol
IRGC
Positive Control 2
Cat. No. 17-208 - A-20 Cell Slide
NCBI Official Name
Immunity-related GTPase family, cinema
NCBI Organism
Homo sapiens
Background Reference 01
Taylor GA. IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens. Cell Microbiol.2007; 9:1099-107.
Background Reference 02
Yamada K, Akimoto H, Ogawa Y, et al. Upregulation of immunity-related GTPase (IRG) proteins by TNF-alpha in murine astrocytes. Biochem. Biophys. Res. Commun.2009; 382:434-9.
Background Reference 03
Singh SB, et al. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science2006; 313:1438-41.
Background Reference 04
Bekpen C, Hunn JP, Rohde C, et al. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol.2005; 6:R92.
Other Product Names
IRGC Antibody: IFGGE, IRGC1, Iigp5, CINEMA, R30953_1, IIGP5, Interferon-inducible GTPase 5, Immunity-related GTPase cinema 1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
10257429
Physical Properties
Liquid

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