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CCDC134 Antibody

CAT: 0223-5265-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5265-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CCDC134 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.
NCBI Gene ID
79879
Swiss Prot
Q9H6E4
Accession Number
NP_079097
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer
Purification
CCDC134 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
CCDC134 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CCDC134 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
CCDC134
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Coiled-coil domain containing 134
NCBI Organism
Homo sapiens
Background Reference 01
Steinmetz MO, Jelesarov I, Matousek WM, et al. Molecular basis of coiled-coil formation. Proc. Natl. Acad. Sci. USA2007; 104:7062-7.
Background Reference 02
Huang J, Shi T, Ma T, et al. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. Cell. Mol. Life Sci.2008; 65:338-49.
Other Product Names
CCDC134 Antibody: dJ821D11.3, Coiled-coil domain-containing protein 134
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
13376216
Physical Properties
Liquid

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