GPR3 Antibody

• Background :

  GPR3 Antibody: GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Abeta in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.

• NCBI Gene ID :

  2827

• Swiss Prot :

  P46089

• Accession Number :

  P46089

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  GPR3 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration :

  1 mg/mL

• Buffer :

  GPR3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  GPR3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  GPR3

• Positive Control 2 :

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name :

  G protein-coupled receptor 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Marchesse A, Docherty JM, Nguyen T, et al. Cloning of human genes encoding novel G protein-coupled receptors. Genomics1994; 23:609-18.

• Background Reference 02 :

  Eggerickx D, Denef JF, Labbe O, et al. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Biochem. J.1995; 309:837-43.

• Background Reference 03 :

  Thathiah A, Spittaels K, Hoffmann M, et al. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science2009; 323:946-951.

• Background Reference 04 :

  Blacker D, Bertram L, Saunder AJ, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum. Mol. Genet.2003; 12:23-32.

• Other Product Names :

  GPR3 Antibody: ACCA, ACCA, G-protein coupled receptor 3, ACCA orphan receptor

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  1170006

• Physical Properties :

  Liquid