PTCHD2 Antibody

• Background:

  PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism.

• NCBI Gene ID:

  57540

• Swiss Prot:

  Q9P2K9

• Accession Number:

  Q9P2K9

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  PTCHD2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 10-701 - Human Testis Tissue Slide

• Concentration:

  1 mg/mL

• Buffer:

  PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PTCHD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins.

• Symbol:

  PTCHD2

• NCBI Official Name:

  Patched domain containing 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Katoh Y and Katoh M. Identification and characterization of DISP3 gene in silico. Int. J. Oncol. 2005; 26:551-6

• Background Reference 02:

  Katoh Y and Katoh M. Hedgehog signaling pathway and gastric cancer. Can. Biol. & Ther. 2005; 4:1050-4

• Background Reference 03:

  Zikova M, Corlett A, Bendova Z, et al. DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism. Mol. Endocrin. 2009; 23:520-8.

• Other Product Names:

  PTCHD2 Antibody: DISP3, DISP3, KIAA1337, Patched domain-containing protein 2, Protein dispatched homolog 3

• Tested Applications:

  ELISA, IHC-P

• Protein ID:

  149274653

• Physical Properties:

  Liquid