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IL-17 Antibody

CAT: 0223-4887-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4887-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.
NCBI Gene ID
3605
Swiss Prot
Q16552
Accession Number
NP_002181
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
4887
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 1) : Anit-IL-17 antibodies (4887) detected human IL-17 recombinant protein at different concentrations Recombinant Protein Test4887
Field of Research
Signal Transduction
Purification
IL-17 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 17-208 - A20 Cell Slide
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (84%), Rat: (81%), Pig: (74%)
Buffer
IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-17 antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human IL-17 has only one isoform (155aa, 17.5kD) . Mouse IL-17 has one isoform (158aa, 17.5kD) and Rat IL-17 also has one isoform (150aa, 16.9kD) . 4887 can detect human, mouse and rat IL-17.
Symbol
IL17A
NCBI Official Name
Interleukin 17A
NCBI Organism
Homo sapiens
Background Reference 01
Miossec. Curr. Opin. Rheumatol.2000; 12:181-5.
Background Reference 02
Paunovic et al. Rheumatol.2008; 47:771-6.
Background Reference 03
Steinman. Nat. Med.2007; 13:139-145.
Other Product Names
IL-17 Antibody: IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4504651
Physical Properties
Liquid

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