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Dact2 Antibody

CAT: 0223-4859-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4859-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dact2 Antibody: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
NCBI Gene ID
168002
Swiss Prot
Q5SW24
Accession Number
NP_999627
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Dact2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Buffer
Dact2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Dact2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
DACT2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
NCBI Organism
Homo sapiens
Background Reference 01
Shimigori T, VanSant J, Paik E, et al. Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex. J. Comp. Neurol.2004; 473:496-510.
Background Reference 02
Cheyette BNR, Waxman JS, Miller JR, et al. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev. Cell2002; 2:449-61.
Background Reference 03
Katoh M and Katoh M. Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. Int. J. Oncol.22:907-13.
Background Reference 04
Waxman JS, Hocking AM, Stoick CL, et al. Zebrafish DAPPER1 and DAPPER2 play distinct roles in Wnt-mediated developmental processes. Development2004; 131:5909-21.
Other Product Names
Dact2 Antibody: DPR2, DAPPER2, C6orf116, bA503C24.7, PP13671, Dapper homolog 2, Dapper antagonist of catenin 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
163965434
Physical Properties
Liquid

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