Gp120 Antibody

• Background:

  Gp120 Antibody: Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.

• NCBI Gene ID:

  155971

• Swiss Prot:

  Q6BBS3

• Accession Number:

  AAB05604

• Host:

  Goat

• Reactivity:

  Virus

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Infectious Disease

• Purification:

  Gp120 Antibody is affinity chromatography purified via peptide column.

• Concentration:

  1 mg/mL

• Buffer:

  Gp120 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Gp120 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Applications Notes:

  Gp120 antibody can be used for detection of gp120 by Western blot at 1 μ g/mL.

• Symbol:

  Env

• NCBI Official Name:

  Envelope glycoprotein

• NCBI Organism:

  Human immunodeficiency virus 1

• Background Reference 01:

  Pinter A. Roles of HIV-1 Env variable regions in viral neutralization and vaccine development. Curr. HIV Res.2007; 5:542-53.

• Background Reference 02:

  Alkhatib G and Berger EA. HIV coreceptors: from discovery and designation to new paradigms and promise. Eur. J. Med. Res.2007; 12:375-84.

• Other Product Names:

  Gp120 Antibody: Envelope glycoprotein gp160

• Tested Applications:

  ELISA, WB

• Protein ID:

  1465781

• Physical Properties:

  Liquid